{"id":16715,"date":"2026-04-12T18:06:56","date_gmt":"2026-04-12T15:06:56","guid":{"rendered":"https:\/\/www.hakanyanar.com\/services\/hipec-treatment-istanbul\/"},"modified":"2026-04-12T21:17:26","modified_gmt":"2026-04-12T18:17:26","slug":"hipec-treatment-istanbul","status":"publish","type":"page","link":"https:\/\/www.hakanyanar.com\/en\/services\/hipec-treatment-istanbul\/","title":{"rendered":"HIPEC Treatment Istanbul"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"16715\" class=\"elementor elementor-16715 elementor-16560\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c73d8cf elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c73d8cf\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3c9cdec\" data-id=\"3c9cdec\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b96e5ed elementor-widget elementor-widget-html\" data-id=\"b96e5ed\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<!DOCTYPE html>\r\n<html lang=\"tr\">\r\n<head>\r\n<meta charset=\"UTF-8\">\r\n<meta name=\"viewport\" content=\"width=device-width, initial-scale=1.0\">\r\n<link href=\"https:\/\/fonts.googleapis.com\/css2?family=Raleway:wght@400;500;600;700;800&family=Cormorant+Garamond:ital,wght@0,400;0,600;1,400&display=swap\" rel=\"stylesheet\">\r\n\r\n<style>\r\n*, *::before, *::after { box-sizing: border-box; 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HIPEC-certified surgeon in Istanbul.<\/p>\r\n  <div class=\"hy-badges\"><span class=\"hy-badge\">\ud83e\uddec HIPEC Certified<\/span><span class=\"hy-badge\">\ud83d\udd2c Cytoreductive Surgery<\/span><span class=\"hy-badge\">\ud83c\udf0d International Patients<\/span><span class=\"hy-badge\">\ud83d\udcc4 50+ International Publications<\/span><\/div>\r\n<\/div>\r\n<div class=\"hy-bc\"><a href=\"\/en\/\">Home<\/a><span class=\"hy-bc-sep\">\u203a<\/span><a href=\"https:\/\/www.hakanyanar.com\/en\/services\/\">Conditions<\/a><span class=\"hy-bc-sep\">\u203a<\/span>HIPEC<\/div>\r\n<div class=\"hy-body hy-cf\">\r\n\r\n<div class=\"hy-sidebar\">\r\n  <div class=\"hy-toc\">\r\n    <div class=\"hy-toc-title\">\ud83d\udccb \u0130\u00e7indekiler<\/div>\r\n    <a href=\"#what-is\">What is HIPEC?<\/a><a href=\"#indications\">Indications<\/a><a href=\"#selection\">Patient Selection<\/a><a href=\"#procedure\">The Procedure<\/a><a href=\"#istanbul\">HIPEC in Istanbul<\/a><a href=\"#faq\">FAQ<\/a>\r\n  <\/div>\r\n  <div class=\"hy-doc-card\">\r\n    <img decoding=\"async\" src=\"https:\/\/www.hakanyanar.com\/wp-content\/uploads\/2022\/01\/hakanyanarliv-2.png\" alt=\"Prof. Dr. Hakan Yanar\" class=\"hy-doc-img\">\r\n    <div class=\"hy-doc-name\">Prof. Dr. Hakan Yanar<\/div>\r\n    <div class=\"hy-doc-title\">Genel Cerrahi & Onkolojik Cerrahi Uzman\u0131<\/div>\r\n    <a href=\"tel:+905301715814\" class=\"hy-doc-btn\">\ud83d\udcde Randevu Al<\/a>\r\n    <a href=\"https:\/\/wa.me\/905301715814\" class=\"hy-doc-btn wa\" target=\"_blank\">\ud83d\udcac WhatsApp<\/a>\r\n  <\/div>\r\n  <div class=\"hy-info-box\">\r\n    <div class=\"hy-info-title\">\u26a1 H\u0131zl\u0131 Bilgiler<\/div>\r\n    <div class=\"hy-info-row\"><span class=\"hy-info-label\">Operating Time<\/span><span class=\"hy-info-val\">6\u201312 hours<\/span><\/div><div class=\"hy-info-row\"><span class=\"hy-info-label\">Hospital Stay<\/span><span class=\"hy-info-val\">7\u201314 days<\/span><\/div><div class=\"hy-info-row\"><span class=\"hy-info-label\">Perfusion Temp.<\/span><span class=\"hy-info-val\">41\u201343\u00b0C<\/span><\/div><div class=\"hy-info-row\"><span class=\"hy-info-label\">Recovery<\/span><span class=\"hy-info-val\">4\u20138 weeks<\/span><\/div><div class=\"hy-info-row\"><span class=\"hy-info-label\">Certification<\/span><span class=\"hy-info-val\">CRS+HIPEC<\/span><\/div><div class=\"hy-info-row\"><span class=\"hy-info-label\">Languages<\/span><span class=\"hy-info-val\">TR \u00b7 EN \u00b7 FR \u00b7 RU<\/span><\/div>\r\n  <\/div>\r\n<\/div>\r\n<div class=\"hy-content\">\r\n\r\n<div class=\"hy-sec\" id=\"what-is\">\r\n<h2>What is HIPEC?<\/h2>\r\n<p class=\"hy-p\"><strong>HIPEC (Hyperthermic Intraperitoneal Chemotherapy)<\/strong> is a locoregional treatment strategy for cancers that have spread to the peritoneum \u2014 the thin membrane lining the inner abdominal wall and covering abdominal organs. It combines <strong>cytoreductive surgery (CRS)<\/strong>, which removes all visible peritoneal tumor deposits, with the intraoperative administration of heated chemotherapy solution directly into the abdominal cavity.<\/p>\r\n<p class=\"hy-p\">The rationale for hyperthermia is dual: temperatures of 41\u201343\u00b0C are directly cytotoxic to tumor cells and enhance drug penetration into tumor tissue. Intraperitoneal delivery achieves drug concentrations 20\u20131,000 times higher than systemic administration, while markedly limiting systemic toxicity.<\/p>\r\n<div class=\"hy-info-alert\"><p>\ud83d\udccc <strong>Important:<\/strong> CRS+HIPEC is a major surgical undertaking. Appropriate patient selection \u2014 by an experienced multidisciplinary oncology team \u2014 is the most critical determinant of outcome. Not all patients with peritoneal metastases are suitable candidates.<\/p><\/div>\r\n<\/div>\r\n\r\n<div class=\"hy-sec\" id=\"indications\">\r\n<h2>Indications<\/h2>\r\n<div class=\"hy-risk-grid\">\r\n<div class=\"hy-risk-item\"><div class=\"hy-risk-icon\">\ud83d\udd2c<\/div><div class=\"hy-risk-title\">Colorectal Cancer<\/div><div class=\"hy-risk-desc\">Peritoneal metastases from colorectal cancer are the most common indication. Selected patients with limited peritoneal disease (low PCI) achieve significantly improved survival with CRS+HIPEC compared with systemic chemotherapy alone.<\/div><\/div>\r\n<div class=\"hy-risk-item\"><div class=\"hy-risk-icon\">\u2695\ufe0f<\/div><div class=\"hy-risk-title\">Gastric Cancer<\/div><div class=\"hy-risk-desc\">CRS+HIPEC is considered for gastric cancer with limited peritoneal metastases or positive peritoneal cytology (P1\/CY1). Stringent patient selection is required; outcomes are best with complete cytoreduction.<\/div><\/div>\r\n<div class=\"hy-risk-item\"><div class=\"hy-risk-icon\">\ud83e\udee7<\/div><div class=\"hy-risk-title\">Pseudomyxoma Peritonei<\/div><div class=\"hy-risk-desc\">Pseudomyxoma peritonei (appendiceal mucinous neoplasms) is one of the strongest indications for CRS+HIPEC, with excellent long-term outcomes including 10-year survival exceeding 60% in experienced centers.<\/div><\/div>\r\n<div class=\"hy-risk-item\"><div class=\"hy-risk-icon\">\ud83e\udec1<\/div><div class=\"hy-risk-title\">Peritoneal Mesothelioma<\/div><div class=\"hy-risk-desc\">Primary peritoneal mesothelioma is a rare but aggressive malignancy for which CRS+HIPEC represents the only potentially curative treatment strategy, offering median survival exceeding 5 years in selected patients.<\/div><\/div>\r\n<\/div>\r\n<\/div>\r\n\r\n<div class=\"hy-sec\" id=\"selection\">\r\n<h2>Patient Selection<\/h2>\r\n<p class=\"hy-p\">Rigorous patient selection is the cornerstone of CRS+HIPEC outcomes. The key eligibility criteria include:<\/p>\r\n<ul class=\"hy-ul\">\r\n<li><strong>Peritoneal Cancer Index (PCI):<\/strong> Quantifies the extent of peritoneal disease across 13 abdominal regions (score 0\u201339). Lower PCI correlates with better outcomes; generally PCI \u226420 for colorectal cancer and PCI \u22646\u201312 for gastric cancer.<\/li>\r\n<li><strong>Completeness of Cytoreduction (CC) score:<\/strong> CC-0 (no residual tumor) is the primary surgical objective and strongest predictor of survival benefit.<\/li>\r\n<li><strong>Performance status:<\/strong> ECOG 0\u20131; adequate cardiopulmonary, hepatic, and renal function.<\/li>\r\n<li><strong>No extra-abdominal metastases:<\/strong> Liver and lung metastases generally exclude patients from curative-intent CRS+HIPEC (with some exceptions for synchronous hepatic resection).<\/li>\r\n<li><strong>Tumor histology:<\/strong> Mucinous appendiceal tumors, mesothelioma, and selected colorectal\/gastric cases have the strongest evidence base.<\/li>\r\n<\/ul>\r\n<div class=\"hy-warn\"><div class=\"hy-warn-title\">\u26a0\ufe0f Multidisciplinary Evaluation is Mandatory<\/div><p>Every patient considered for CRS+HIPEC must be evaluated by a multidisciplinary oncology board including surgical oncology, medical oncology, radiology, and pathology. No patient proceeds to surgery without board consensus.<\/p><\/div>\r\n<\/div>\r\n\r\n<div class=\"hy-sec\" id=\"procedure\">\r\n<h2>The Procedure<\/h2>\r\n\r\n<div class=\"hy-treat-card\">\r\n<div class=\"hy-treat-head\">\r\n<div class=\"hy-treat-icon\">\ud83e\uddec<\/div>\r\n<div class=\"hy-treat-title\">CRS + HIPEC \u2014 Combined Procedure<\/div>\r\n<div class=\"hy-treat-badge\">Major Oncological Surgery<\/div>\r\n<\/div>\r\n<div class=\"hy-treat-body\">\r\n<div class=\"hy-treat-stats\"><div class=\"hy-treat-stat\"><span class=\"hy-treat-stat-val\">6\u201312 hrs<\/span><span class=\"hy-treat-stat-lbl\">Total operating time<\/span><\/div><div class=\"hy-treat-stat\"><span class=\"hy-treat-stat-val\">41\u201343\u00b0C<\/span><span class=\"hy-treat-stat-lbl\">Perfusion temperature<\/span><\/div><div class=\"hy-treat-stat\"><span class=\"hy-treat-stat-val\">60\u201390 min<\/span><span class=\"hy-treat-stat-lbl\">HIPEC perfusion<\/span><\/div><div class=\"hy-treat-stat\"><span class=\"hy-treat-stat-val\">7\u201314 days<\/span><span class=\"hy-treat-stat-lbl\">Hospital stay<\/span><\/div><\/div>\r\n<p><strong>Phase 1 \u2014 Cytoreductive Surgery:<\/strong> All visible peritoneal tumor deposits are systematically excised. This may include peritonectomy procedures (parietal and visceral peritoneum stripping), omentectomy, and resection of involved organs (bowel, spleen, gallbladder, uterus\/ovaries). Complete cytoreduction (CC-0) is the primary oncological objective.<\/p><p><strong>Phase 2 \u2014 HIPEC:<\/strong> Immediately following cytoreduction, a heated chemotherapy solution (typically oxaliplatin or mitomycin C for colorectal cancer; cisplatin for mesothelioma) is circulated through the abdominal cavity at 41\u201343\u00b0C for 60\u201390 minutes using a closed or open (coliseum) technique. The abdomen is then irrigated and closed.<\/p>\r\n<ul class=\"hy-treat-points\"><li>Complete cytoreduction (CC-0) is the strongest predictor of benefit<\/li><li>Drug concentrations 20\u20131,000\u00d7 higher than systemic chemotherapy<\/li><li>Hyperthermia enhances drug uptake and is directly cytotoxic<\/li><li>HIPEC-certified surgeon and experienced team essential<\/li><\/ul>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n\r\n<div class=\"hy-sec\" id=\"istanbul\">\r\n<div class=\"hy-istanbul\">\r\n<h2>HIPEC in Istanbul<\/h2>\r\n<p class=\"hy-p\">Prof. Dr. Hakan Yanar holds certification in cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS+HIPEC) and is one of the few surgeons in Istanbul performing this procedure at Liv Hospital Ulus. International candidates for HIPEC are evaluated through a structured multidisciplinary process, with consultations available in English, French, and Russian.<\/p>\r\n<\/div>\r\n<\/div>\r\n\r\n<script type=\"application\/ld+json\">\r\n{\"@context\":\"https:\/\/schema.org\",\"@type\":\"FAQPage\",\"mainEntity\":[{\"@type\":\"Question\",\"name\":\"What is HIPEC?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"HIPEC (hyperthermic intraperitoneal chemotherapy) is a surgical procedure in which heated chemotherapy solution (41\u201343\u00b0C) is circulated through the abdominal cavity immediately after cytoreductive surgery (CRS). It is used to treat cancers that have spread to the peritoneum \u2014 the membrane lining the abdominal cavity.\"}},\r\n{\"@type\":\"Question\",\"name\":\"Which cancers can be treated with HIPEC?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"The most common indications include peritoneal metastases from colorectal cancer, gastric cancer, appendiceal tumors (pseudomyxoma peritonei), primary peritoneal mesothelioma, and selected cases of ovarian cancer. Patient selection is critical and requires multidisciplinary oncology board review.\"}},\r\n{\"@type\":\"Question\",\"name\":\"How does heated chemotherapy work?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Hyperthermia at 41\u201343\u00b0C directly damages tumor cells, enhances drug uptake by malignant tissue, and overcomes some mechanisms of chemotherapy resistance. 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These risks are substantially reduced when the procedure is performed by an experienced, HIPEC-certified surgical team at a high-volume center.\"}},\r\n{\"@type\":\"Question\",\"name\":\"Is Prof. Dr. Hakan Yanar HIPEC-certified?\",\"acceptedAnswer\":{\"@type\":\"Answer\",\"text\":\"Yes. Prof. Dr. Hakan Yanar holds certification in cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS+HIPEC) and is one of the few surgeons in Istanbul performing this procedure. All candidates are evaluated by a multidisciplinary oncology board before proceeding.\"}}]}\r\n<\/script><div class=\"hy-sec\" id=\"faq\"><h2>S\u0131k Sorulan Sorular<\/h2><div class=\"hy-faq-item\"><div class=\"hy-faq-q\">What is HIPEC?<\/div><div class=\"hy-faq-a\">HIPEC (hyperthermic intraperitoneal chemotherapy) is a surgical procedure in which heated chemotherapy solution (41\u201343\u00b0C) is circulated through the abdominal cavity immediately after cytoreductive surgery (CRS). It is used to treat cancers that have spread to the peritoneum \u2014 the membrane lining the abdominal cavity.<\/div><\/div><div class=\"hy-faq-item\"><div class=\"hy-faq-q\">Which cancers can be treated with HIPEC?<\/div><div class=\"hy-faq-a\">The most common indications include peritoneal metastases from colorectal cancer, gastric cancer, appendiceal tumors (pseudomyxoma peritonei), primary peritoneal mesothelioma, and selected cases of ovarian cancer. Patient selection is critical and requires multidisciplinary oncology board review.<\/div><\/div><div class=\"hy-faq-item\"><div class=\"hy-faq-q\">How does heated chemotherapy work?<\/div><div class=\"hy-faq-a\">Hyperthermia at 41\u201343\u00b0C directly damages tumor cells, enhances drug uptake by malignant tissue, and overcomes some mechanisms of chemotherapy resistance. Direct intraperitoneal delivery achieves drug concentrations 20\u20131,000 times higher than systemic chemotherapy while limiting systemic toxicity.<\/div><\/div><div class=\"hy-faq-item\"><div class=\"hy-faq-q\">What is cytoreductive surgery (CRS)?<\/div><div class=\"hy-faq-a\">Cytoreductive surgery aims to remove all visible peritoneal tumor deposits. Complete cytoreduction (CC-0: no residual tumor) is the most important predictor of survival benefit from HIPEC. The extent of peritoneal involvement is quantified by the Peritoneal Cancer Index (PCI).<\/div><\/div><div class=\"hy-faq-item\"><div class=\"hy-faq-q\">Who is a candidate for CRS+HIPEC?<\/div><div class=\"hy-faq-a\">Ideal candidates have limited peritoneal disease (low PCI score), good performance status (ECOG 0\u20131), no extra-abdominal metastases, and tumor histology amenable to the procedure. Careful patient selection by an experienced multidisciplinary team is essential to maximize benefit and minimize risk.<\/div><\/div><div class=\"hy-faq-item\"><div class=\"hy-faq-q\">How long does CRS+HIPEC take?<\/div><div class=\"hy-faq-a\">The combined procedure typically takes 6\u201312 hours depending on the extent of cytoreduction required. It is a major operation performed under general anesthesia. Hospital stay is typically 7\u201314 days, with full recovery requiring 4\u20138 weeks.<\/div><\/div><div class=\"hy-faq-item\"><div class=\"hy-faq-q\">What are the risks of HIPEC?<\/div><div class=\"hy-faq-a\">As a major abdominal procedure, CRS+HIPEC carries risks including anastomotic leak, wound complications, hematological toxicity from intraperitoneal chemotherapy, and prolonged ileus. These risks are substantially reduced when the procedure is performed by an experienced, HIPEC-certified surgical team at a high-volume center.<\/div><\/div><div class=\"hy-faq-item\"><div class=\"hy-faq-q\">Is Prof. Dr. Hakan Yanar HIPEC-certified?<\/div><div class=\"hy-faq-a\">Yes. Prof. Dr. Hakan Yanar holds certification in cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS+HIPEC) and is one of the few surgeons in Istanbul performing this procedure. All candidates are evaluated by a multidisciplinary oncology board before proceeding.<\/div><\/div><\/div>\r\n\r\n<div class=\"hy-cta\">\r\n  <h3>Book a HIPEC Consultation<\/h3>\r\n  <p>Contact Prof. Dr. Hakan Yanar to evaluate your candidacy for CRS+HIPEC in Istanbul.<\/p>\r\n  <div class=\"hy-cta-btns\">\r\n    <a href=\"tel:+905301715814\" class=\"hy-cta-btn primary\">\ud83d\udcde Hemen Ara<\/a>\r\n    <a href=\"https:\/\/wa.me\/905301715814\" class=\"hy-cta-btn wa\" target=\"_blank\">\ud83d\udcac WhatsApp ile Yaz<\/a>\r\n    <a href=\"\/iletisim\/\" class=\"hy-cta-btn primary\">\ud83d\udcc5 Online Randevu<\/a>\r\n  <\/div>\r\n<\/div>\r\n<div class=\"hy-related\"><h3>\u0130lgili Hastal\u0131k ve Tedaviler<\/h3><div class=\"hy-related-grid hy-cf\"><div class=\"hy-related-card\"><div class=\"hy-related-icon\">\ud83d\udd2c<\/div><div class=\"hy-related-name\">Colorectal Cancer<\/div><div class=\"hy-related-desc\">Laparoscopic surgery<\/div><a href=\"\/en\/services\/colon-rectal-cancer\/\" class=\"hy-related-link\">Detayl\u0131 \u0130ncele \u2192<\/a><\/div><div class=\"hy-related-card\"><div class=\"hy-related-icon\">\u2695\ufe0f<\/div><div class=\"hy-related-name\">Gastric Cancer<\/div><div class=\"hy-related-desc\">Laparoscopic gastrectomy<\/div><a href=\"\/en\/services\/gastric-cancer\/\" class=\"hy-related-link\">Detayl\u0131 \u0130ncele \u2192<\/a><\/div><div class=\"hy-related-card\"><div class=\"hy-related-icon\">\ud83e\udd16<\/div><div class=\"hy-related-name\">Robotic Surgery<\/div><div class=\"hy-related-desc\">Minimally invasive technology<\/div><a href=\"\/en\/services\/laparoscopic-robotic-surgery\/\" class=\"hy-related-link\">Detayl\u0131 \u0130ncele \u2192<\/a><\/div><\/div><\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/body>\r\n<\/html>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Oncological Surgery \u00b7 Istanbul HIPEC Treatment Prof. Dr. Hakan Yanar \u2014 General Surgery &#038; Oncological Surgery Specialist Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS+HIPEC) for peritoneal surface malignancies. HIPEC-certified surgeon in Istanbul. \ud83e\uddec HIPEC Certified\ud83d\udd2c Cytoreductive Surgery\ud83c\udf0d International Patients\ud83d\udcc4 50+ International Publications Home\u203aConditions\u203aHIPEC \ud83d\udccb \u0130\u00e7indekiler What is HIPEC?IndicationsPatient SelectionThe ProcedureHIPEC in IstanbulFAQ Prof. Dr. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":15980,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-16715","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v21.7 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>HIPEC Treatment Istanbul &#8212; Prof. Dr. Hakan Yanar<\/title>\n<meta name=\"description\" content=\"HIPEC (hyperthermic intraperitoneal chemotherapy) for peritoneal cancer in Istanbul. 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HIPEC-certified surgeon Prof. Dr. Hakan Yanar. 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