fbpx
Rektum Kanseri
09/25/2019

VOLUME 105, ISSUE 1, SUPPLEMENT , E163-E164, SEPTEMBER 01, 2019
DOI:https://doi.org/10.1016/j.ijrobp.2019.06.2138

Purpose/Objective(s): The number and status of lymph nodes (LN) examined is accepted as one of the main prognostic factors in patients with rectal cancer. However, the prognostic role of number of LN evaluation in patients who receive preoperative treatment is unclear. The aim of this study is to define the impact of preoperative short course radiotherapy (SCRT) on the number of both retrieved and positive LN and to evaluate the influence of the number of LN retrieved on survival.

Materials/Methods: From 2011 to 2017, 75 patients who underwent preoperative SCRT followed by mesorectal excision for rectal cancer were evaluated. Patient and tumor characteristics were evaluated. LN numbers were evaluated in two different groups as following: 1- being less or more than 12 as the standard LN number to be retrieved in primary colorectal cancer surgery, 2- being less or more that the median number of LN for the present study. Overall survival(OS) and progression free survival (PFS) were analyzed using Kaplan–Meier for the whole group and according to LN groups. Univariate analysis was performed. Moreover the correlations between mass index (BMI), clinical N stage , SCRT-surgery interval, pathologic N stage, tumor regression grade and LN number, positive LN number, positive LN ratio were evaluated with Pearson’s correlation.

Results: Median follow-up was 34 months. Patient and tumor characteristics are shown in Table 1. There was no significant difference between OS and PFS. However there were negative correlations between RT-surgery interval and total LN number ( r=-0.9), positive LN number (r=-0.1) and positive LN/total LN ratio(r=-0.3). Total LN number and positive LN number were correlated (r=0.4).

Conclusion: In this study, the total number of LN retrieved was not associated with OS and PFS. This may be related to the retrospective nature of the study as well as the limited number of patients included and having a high median LN retrieval number. On the other hand, however there were negative correlations between RT-surgery interval and total LN number, positive LN number and positive LN/total LN ratio. Total LN number and positive LN number were also correlated.

Prof.Dr. Hakan Yanar 1971 yılında Denizli’ de doğdu. İlk, orta ve lise öğrenimini Denizli’ de tamamlamasını takiben 1988’de İstanbul Tıp Fakültesini kazandı. Cerrahi intörnlüğünü University of Colorado Health Science Center, Denver Colorado’ da tamamladı. Mecburi hizmetini 1995-1996 yılları arasında Isparta’da, askerlik hizmetini Nisan 2000’de Tunceli’ de yerine getirdi. 1996 yılında İstanbul Tıp Fakültesi Genel Cerrahi Anabilim Dalı’nda başladığı Genel Cerrahi ihtisasını “Kolon anastomozlarında skar dokusu oluşumu ve latirojen ilaçların etkisi” isimli tez ile Haziran 2001’ de tamamladı. Şubat 2006-Şubat 2007 arasında University of Southern California Medical Center, Department of General Surgery, Los Angeles, ABD’ de çalıştı. Primer cerrahi ilgi alanı gastrointestinal hastalıklar, mide, kolon ve rektum kanseri başta olmak onkolojik cerrahi olguların laparoskopik tedavisi üzerine odaklanmıştır. “Robotik Cerrahi” ve “Cytoreductive surgery (CRS) and Hypertermic intraperitoneal chemotherapy (HIPEC) in Peritoneal Surface Malignancy” sertifikalarına sahiptir. Türk Cerrahi Derneği, Hepato-Pankreato-Bilier Cerrahi Derneği, İstanbul Tabib Odası üyesi, Ulusal Travma ve Acil Cerrahi Derneği ile Ulusal Endoskopik Laparoskopik Cerrahi Derneği yönetim kurulu üyesidir. Ulusal Travma ve Acil Cerrahi Dergisi’nde yardımcı editörlük, European Society of Trauma and Emergency Surgery (ESTES) Emergency Section’ da Chairman ve Türkiye delegeliği görevlerini yerine getirmektedir. Elli uluslararası, 20 ulusal çalışmasıhakemli dergilerde yayınlanmıştır. İki uluslararası, on ulusal kitap bölümü bulunmaktadır. Çok sayıda sözlü ve poster sunumu, yurt içi ve yurt dışı panel ve sempozyum konuşmaları gerçekleştirmiştir. İki uluslararası, çok sayıda ulusal kitap bölümü yazımı ve çevirisi bulunmaktadır. Ekim 2008’ de Doçent, Mart 2014′te profesör ünvanını alan Prof.Dr. Hakan Yanar İngilizce bilmektedir. Evli, bir kız ve bir erkek çocuk babasıdır.

Benzer Makaleler